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Also studied was the combined application of N G -nitro-L-arginine methylester (L-NAME) (5 mg/kg i.v.), a competitive inhibitor of endothelium nitric oxide (NO)-generation and the NO-precursor L-arginine (200 mg/kg i.v.) (D-arginine was ineffective)

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GSSSG inhibits LPS-induced phosphorylation of TAK1 in BV-2 cells The data from our preliminary test using arrays of antibodies against intracellular signaling molecules suggested that GSSSG administration inhibited TGF-β-activated kinase 1 (TAK1) phosphorylated at the serine 412 residue in BV-2 cells treated with both GSSSG and LPS compared to those treated with LPS alone (Supplementary Fig